INST develops nanotechnology-based method for production of ‘Rufinamide’

DST takes several nanotechnology initiatives that contribute to an Atamnirbhar Bharat

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INST develops nanotechnology-based low-cost, method for the production of antiepileptic drug ‘Rufinamide’. Photo by James Yarema on Unsplash

Scientists at the Institute of Nano Science and Technology (INST), an autonomous institute of the Department of Science and Technology (DST), Government of India, have developed a nanotechnology-based industry-friendly and low-cost method for the production of antiepileptic drug ‘Rufinamide’.

Jayamurugan Govindasamy and his co-workers from INST have developed a new recyclable copper-oxide catalyst, which plays a crucial role in the key reaction for producing the Rufinamide drug.

The existing technology for producing the drug has an inherent selectivity issue, often leading to unwanted non-drug isomer -1, 5-regioisomer. This necessitates the use of organic solvent, high temperature, and the need to purify and separate the soluble catalyst and so on, leading to unfriendly reaction conditions and high production costs.

In the new production method published in the journal Chemical Communications, unlike the traditional CuSO4 catalyst, the newly designed catalyst comprising of very small-sized (3 to 5 nm) CuI and CuII are so reactive that the reaction can be conducted efficiently under the aqueous condition and at room temperature. Since the catalyst is coated with slightly modified natural bio-polymer, they are biocompatible and can be separated just by filtration technique.

According to the press release, the new method promises to overcome many of the current challenges in the synthesis of Rufinamide drugs such as high cost, the formation of unwanted 1,5-regioisomer in addition to the required 1,4-regioisomer, limited choice of starting materials (propiolic acid derivatives) leading to multistep synthetic sequences, and poor yields due to use of organic solvents and overheating of the reagents.

Govindasamy, a Ramanujan Fellow of DST, and his co-workers used nanotechnology to develop the new recyclable copper-oxide catalyst supported by customized bio-polymer (available abundantly from biomass). The synthesized catalyst turned out to be highly active in aqueous solvents, making manufacture possible under industrial friendly conditions.

The developed catalyst is useful not only for the Rufinamide drug synthesis but also for other organic transformation reactions. The catalyst can be commercialized for academic use, as well as companies deal with fine chemicals that use these reactions.

Having been well optimized under laboratory conditions in the 10 g scale, the catalytic process can be easily translated into the industrial process, the release states. Furthermore, because the choice of metal and the polymers are so cheap, the end product of the present catalytic process can be maintained at low-cost. A patent has been filed for the highly efficient, economical, and eco-friendly process.

Presently only a few companies manufacture the costly Rufinamide drug, which epilepsy patients need to consume continuously for their entire life. Hence, the catalytic process developed by the INST team can be used by Active Pharmaceutical Ingredient, producing companies for mass production to bring down the drug cost.

“Several nanotechnology initiatives of DST in seeding the infrastructure, human resources, and the Institute of Nanoscience and Technology are now increasingly producing many useful technologies and products that contribute to an AtamNirbhar Bharat,” said Ashutosh Sharma, secretary, DST.

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