Royal Philips, a health technology company, has announced the establishment of the first-ever global consensus for the appropriate use of intravascular ultrasound (IVUS) in lower extremity arterial and venous interventions.
The company said in a statement that it is an important milestone in the evolving standard of care for treating patients with peripheral vascular disease (PVD).
Published in the August 2022 issue of the Journal of the American College of Cardiology – Cardiovascular Interventions, ‘Appropriate Use of Intravascular Ultrasound During Arterial and Venous Lower Extremity Interventions’ is a new consensus document from 30 global vascular experts. It recommends the routine use of IVUS as a preferred imaging modality in all phases of many peripheral vascular disease (PVD) procedures.
“The voting panelists considered a variety of clinical scenarios and, based on their extensive experience, arrived at a strong consensus,” lead author Eric A Secemsky, an interventional cardiologist at Beth Israel Deaconess Medical Center and assistant professor of medicine at Harvard Medical School, Boston, said.
“They recommend routine use of IVUS as a preferred imaging modality in all phases for many peripheral interventions, both diagnostic and therapeutic, as it enables such exquisite visualization of the target vessel and lesion. Their recommendations, which withstood the rigor of peer review, can now be considered in formulating clinical guidelines for diagnosing and treating peripheral vascular disease,” Secemsky said.
According to the American Heart Association, PVD affects an estimated 200 million people worldwide, including approximately 40 to 45 million Americans.
The authors noted that minimally invasive approaches for PVD interventions are increasingly common, but traditional imaging techniques such as angiography have limitations, including two-dimensional projections of three-dimensional vasculature, which can complicate diagnosis and intraprocedural optimization.
“As the global leader in providing vascular solutions to physicians and the patients they serve, we especially value the rigor and independence of this cross-specialty expert consensus,” said Heather Hudnut Page, general manager and business leader for peripheral vascular image-guided therapy devices at Philips. “It is exciting to know that this initiative has the potential to standardize the use of IVUS in peripheral interventions and guide clinical decisions further to improve the quality of care procedures for patients.”
Supported in part by research grants from Philips and Boston Scientific, the study was conducted and analyzed independently by Smith Center for Outcomes Research, gathering a broad spectrum of vascular expert opinion to ascertain the role of intravascular imaging in contemporary clinical practice.
The broad, multi-disciplinary, global experts used a rigorous RAND/University of California, Los Angeles appropriateness method to achieve consensus. The writing committee generated a systematic and comprehensive list of key clinical scenarios and the role of IVUS in decision-making pathways before voting by a separate committee of world experts in the field who were blind to each other’s responses.
The initial results of their work were first shared at a special symposium during the 2021 Vascular Interventional Advances (VIVA) annual meeting. Subsequently, the Smith Center for Outcomes Research team released a Systematic Literature Review (SLR), summarizing and systematically appraising the number of observational cohort studies in the peripheral vascular space before the late-breaking RCT data from Australia demonstrating the benefits of IVUS guidance in PVD patients.
Dr Secemsky also published a contemporary review in EuroIntervention, showing how IVUS imaging can standardize daily practice decisions through a data-driven approach. In the current JACC – Cardiovascular Interventions publication, the experts established clinical agreement to identify the optimal use of IVUS and potential gaps to set a standard across medical subspecialties to drive positive patient outcomes.
“Lack of clarity in the appropriate use of IVUS in peripheral vascular procedures has raised important questions in daily interventional practice,” said Sahil Parikh, director of endovascular services at the Columbia University Irving Medical Center. “Establishing the appropriate use criteria recommendations is a historical milestone and foundational step towards improving the quality and safety of peripheral vascular procedures.”